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Extracting and concentrating equipment

GXCX-type high-performance chromatography column

My company's own development and production of high-efficiency GXCX chromatography, chromatography device is highly efficient in the finale to the linear flow technology using equipment with 0.5 specification type 600 series 10 varieties, with fast separation speed, short working hours, the efficiency of purification.
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Detailed description

product description
GXCX high-efficiency chromatography column is developed by our company, which is a high-efficiency chromatographic device with medium-pressure axial linear flow technology.It is equipped with 0.5 type 600 series specifications of 10 varieties, with separation speed, short working time, high purification efficiency, (Chinese medicine, pesticide) natural plant, marine biology, biochemical products, genetic engineering and other industries (chemical, food, pharmaceuticals, etc.), the use of a wide range of advantages, easy to operate, the application of a wide range of advantages.Use the difficult to separate materials used to improve work efficiency, are widely used.
in view of our company's technical strength and rich production experience, in recent years, combined with the status quo extraction and separation of production technology and user demand, in order to be a reasonable choice selection of technical solutions and sophisticated equipment, but also to ensure high quality and reliable Of the manufacturing quality. My company at the same time in the tooling technology, means of detection and product design, and other aspects of continuous improvement and maturing, has made gratifying achievements gratifying, the level of technology and product quality in the country are in a leading position.
Equipment characteristics
GXCX high-performance chromatography devices are composed of the main components such as the solvent-liquid tank, the pressure pump (or nitrogen), the multi-stage switching solenoid valve, the control valve, the controller, the packing (stationary phase) column and the detector. technology are as follows:
① the feed tank
. tank to accept material feed, eluent, cleaning agents special containers were assembled frequency magnetic stirring and without stirring two models, in order to achieve continuous operation and efficient quick change function features.
② the pressure pump
pressure pump is used to feed the chromatography column, elution, cleaning supplying the working fluid to the working pressure is high, low traffic, good stability, not to destroy its active substance and the advantages of no leakage of liquid. for this reason the configuration of the pump selection is very important, the ability to work in the separation process, and the importance of having the shape of the pump.
③ multi-stage solenoid valve system
when the material feed work When the shift cleaning agent system, the application of manual and automatic two technical forms, to achieve the entire system piping connections, switching the exact purpose of the technology, the application of automatic technology, can replace the cumbersome manual operation improve the efficiency and reliability without leakage of the solvent to make the machine more compact and to work in unison.
④ controller
control product is the command center of the whole work, in front of the controller is equipped with highly efficient micro static mixer , The pre-filter, in addition to bubble. In order to ensure a balanced distribution of materials and eluent effective mixing, the controller plays a key role, the controller at the same time the pressure pump, solution flow, flow more effective protection and regulation.
⑤ true material (stationary phase) column
mechanism cylinder design, precision manufacturing, guide the rational distribution of fluid and precise filtration area calculations, and can achieve high-speed linear fluid flow rate is to determine the success of the separation The key technology.To this end our company brings together the international advanced technology to update the design of the column structure to successfully solve the rotation of the cylinder 180 ° operability, so that loading and unloading filler is more convenient.
⑥ detector
according to varying process conditions, or the selection can be recommended for users equipped with various detectors in order to isolate the detection and tracking of all process equipment records.
Efficient chromatography apparatus have the following technical characteristics and use of the advantages of conventional chromatography columns can not be compared.
1. facilitate the original process on the basis of linear amplification, improve student efficiency, shorten time to market production Lu drainage.
2. at low flow rates can be linear, and a large flow rate, use, improve production efficiency, the flow rate may be increased by 5 times -15 times.
3. to improve packing efficiency, the unit volume of the amount of filler to achieve the highest binding capacity, especially in industrial production .
4. reduce separation time, so that the products have high activity and yield, with significant economy;
5. Replace the filler may be cylinder rotating 180 °, easy disassembly is convenient, easy to operate, reduce cross-contamination, in line with the GMP process requirements.
7. the bed height is moderate, to ensure low back pressure.
8. packing (stationary phase) column, no dead volume.
can achieve operating under nitrogen pressure and high-pressure pump conditions, under normal circumstances, 0.5L-10L of column options with pressurized nitrogen gas, saving investment, more than 50 high-pressure pump can be used, to improve work efficiency.
according to the actual demand, the process conditions can be column and other ancillary equipment to optimize the combination to achieve the best investment results .
Technical Parameters 

GXCX-type high-performance chromatography column basic parameters as follows:

Column effective volume L

diameterØ=mm

heighth=mm

diameter height ratio (low, high)

working pressure Mpa

Remarks

0.5

35

750

1:20 1:30

0.3

Mobile phase transport - nitrogen

1

50

1000

1:1 1:20

0.3

Mobile phase transport - nitrogen

10

100

1300

1:1 1:20

0.3

Mobile phase transport - Nitrogen or pump

50

150

1800

1:0.5 1:20

0.3

Mobile phase transport - Nitrogen or pump

100

200

2000

1:4 1:20

0.3

Mobile phase transfer - pump

200

250

3000

1:6 1:20

0.3

Mobile phase transfer - pump

400

300

3000

1:10 1:20

0.3

Mobile phase transfer - pump

600

300

3000

1:6 1:10

0.3

Mobile phase transfer - pump

Note: 1. Material selection according to the process requirements, the use of stainless steel SUS304, SS316L. Or coating nickel-phosphorus. 2. Users have special requirements can be designed and manufactured.
It is widely used in the fields of medicine, medicine, food, fine chemicals, natural plants, marine biology, biochemical products, genetic engineering and so on, with good usability and separation effect.

Applications The following table shows the usage

industry

Typical material

industry

Typical material

industry

Typical material

medicine

Yew

Chemical industry

Monoclonal antibodies

food

Capsaicin

Alkaloids

Natural pigments

Lycopene

Cucurbitacin

Inositol

Natural Vitamin E

Flavonoid glycosides

Chlorophyll

carbohydrate

Coumarin

Fluorescent whitening agent

Phosphate

Antibiotics

/ RTI & gt;

Cholesterol

Pharmaceutical intermediates category

Ethyl sulfone sulfuric acid

spices

Corn oil

Biological Engineering

Core sugar nucleic acid

pesticide

Avermectin

Oxidized terpenes

Human white IL-2 concentrated drug

Carbamates

Lime type

Interference

Pyrethrin series

Triterpene acids

Proteins

Herbicides

Leaving alcohol compounds


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